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KMID : 1161420180210090899
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Journal of Medicinal Food
2018 Volume.21 No. 9 p.899 ~ p.904
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Posttreatment Effects of Olea Europaea L. Leaf Extract on Carbon Tetrachloride-Induced Liver Injury and Oxidative Stress in Rats
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Ustuner Derya
Colak Emine
Dincer Murat
Tekin Neslihan
Donmez Dilek Burukoglu
Akyuz Fahrettin
Colak Ertugrul
Kolac Umut Kerem
Entok Emre
Ustuner Mehmet Cengiz
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Abstract
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The aim of this study is to examine the therapeutic effects of Olea europaea L. leaf extract on carbon tetrachloride (CCl4)-induced liver damage in rats. In the experiments, 3- to 4-month-old 28 male Sprague?Dawley rats were divided into four groups: control, O. europaea leaf extract, CCl4, and curative. The CCl4 and curative groups received CCl4 (0.2?mL/kg) intraperitoneally for 10 days to form hepatic injury. O. europaea (80?mg/kg) leaf extract was given orally to the curative group dissolved in distilled water the following 14 days. Hepatic and antioxidant enzyme levels, p53, caspase 3, lipid peroxidation marker malondialdehyde (MDA), and also DNA fragmentation levels were determined to establish oxidative stress in hepatic cell damage and its consequences. After formation of liver damage, oral administration of the O. europaea significantly reduced CCl4-induced elevations of serum alkaline phosphatase, aspartate aminotransferase and alanine aminotransferase levels (P?
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KEYWORD
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antioxidants, DNA fragmentation, liver damage, p53
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